Apply
Organic synthesis. Ethylsalicylic acid inhibits the production of prostables by inhibiting the cyclooxygenase (prostaglandin H synthase), in particular for the COX-1 isotype. The anti-thrombotic effect is due to the inhibition of the COX-1 that plays a role in blood coagulation and platelet aggregation in the platelets.
product Presentation
No smell. The microstrip is sour. stable in dry air and gradually hydrolyzed to salicylic acid and acetic acid in moist air. in case of boiling water or dissolved in sodium hydroxide alkali solution and carbonate alkali solution all decomposed. soluble in ethanol, ether and chloroform.
Biochemical Mechanism
The COX-1 subtype has a higher selectivity by inhibiting the generation of prostaglandins by inhibiting the cyclooxygenase (prostaglandin H synthase). It is possible to inhibit the expression of COX-1 in platelets, thereby blocking the formation of thromboxane and platelet aggregation, thereby having an antithrombotic effect. A chemical control agent for colorectal and other solid tumors.
Alias
2-acetic acid-based benzoic acid; aspirin; glyoxylic acid; acuminate; o-acetic acid-based benzoic acid; o-ethoxybase salicylic acid; 2-ethoxybenzoic acid; O-acetylsalicylic acid; ASA2-Acetooxybenzoic acid; O-Acetoysalicylic acid; Amirin; ASA
Acetylsalicylic acid Basic Information CAS No. 50-78-2:
Product Name |
Acetylsalicylic acid |
Synonyms |
O-ACETYLSALICYLIC ACID; O-ACETOXYBENZOIC ACID; ACETICYL; ACETOXYBENZOIC ACID |
CAS |
50-78-2 |
MF |
C9H8O4 |
MW |
180.16 |
EINECS |
200-064-1 |
Product Categories |
Pharmaceutical; Aromatics Compounds; Aromatics; |
Acetylsalicylic acid Chemical Properties CAS No.50-78-2:
Melting point |
134-136 °C(lit.) |
Boiling point |
272.96°C (rough estimate) |
density |
1.35 |
Fp |
250 °C |
storage temp. |
Store at RT. |
solubility |
H2O: 10 mg/mL at 37 °C |
Water Solubility |
3.3 g/L (20 ºC) |
Merck |
14,851 |
Acetylsalicylic acid Spec:
Items |
Standard |
Appearance |
White Crystalline Powder |
Appearance of Solution |
Clear and Colorless |
Assay |
≥99.0% |
Melting Point |
134-136 °C |
Boiling Point |
140°C |
Flash Point |
250 °C |
Chloride(%) |
≤0.014 |
Sulfate(%) |
≤0.04 |
Limit of free salicylic acid(%) |
≤0.1 |
Heavy metals |
≤10PPM |
Loss on drying(%) |
≤0.5 |
Residue on ignition(%) |
≤0.05 |
Refractive Index |
1.5623(20C) |
Related substances(disregard<0.03%)impurity A(%) |
≤0.15 |
Impurity B(%) |
≤0.15 |
Impurity C(%) |
≤0.15 |
Impurity D(%) |
≤0.15 |
Impurity E(%) |
≤0.15 |
Impurity F(%) |
≤0.15 |
Unspecified Impurities(%) |
≤0.05 |
Total impurities(%) |
≤0.25 |
http://www.zhonghekexin.net/